Atrial Fibrillation (AF), is the most common arryhtmia in the general population. Genome-wide asssociation studies have identified several loci associated with AF. One plausible mechanism of how these genetic variants affect AF is by altering gene expression.

The analysis of genetic control of gene expression in human atrial tissue identified potential functional SNPs that alter gene expression at AF GWAS loci. These SNPs are likely candidates for the causative genetic variants responsible for AF susceptibility and can be queried on . You can see if your favorite gene has an eQTL in the heart by clicking here an address such as: http://afeqtl.lerner.ccf.org/eqtls/CAV1, where CAV1 can be replaced by any gene symbol. Single-nucleotide polymorphisms can also be looked up in the same manner http://afeqtl.lerner.ccf.org/eqtls/rs10824026. An eqtls browser can also be found here: /browser/. A search bar is provided in the upper right.

Citation: Hsu J., Castel L., Lovano B., Moravec C.S., et. al The genetic control of left atrial gene expression yields insights into the genetic susceptibility for atrial fibrillation (2015). In submission.